Might be a lead. I found a Isaac Webb, in MO in 1840, he purchased land in 1844, Camden, MO. On 1850 census is a Sarah Webb, b VA 1803, with her children in Camden MO. Her first 3 children were born in TN.
1840 United States Federal Census
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Name Isaac Webb
Home in 1840 (City, County, State) Pulaski, Missouri
U.S. General Land Office Records, 1776-2015
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Name Isaac Webb
Issue Date 10 Sep 1844
Place Camden, Missouri, USA
Land Office Springfield
Meridian 5th PM
Township 37-N
Range 16-W
Section 14
Accession Number MO5200__.393
Document Number 4320
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1850 United States Federal Census
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Record details
Name Sarah Webb
Gender Female
Race White
Age 47
Birth Year 1803
Birthplace Virginia
Home in 1850 District 13, Camden, Missouri, USA
Cannot Read, Write Yes
Line Number 19
Dwelling Number 242
Family Number 242
Household members
Name Age
Sarah Webb 47
Nancy Webb 26
Alexander Webb 23
Elizabeth Webb 17
Marion Webb 16
Angeline Webb 14
Sarah Webb 12
Washington Webb 8
John Webb 3