I have also seen the "your draft is fully saved and up to date" message that Margaret describes. To get around it, I have made an inconsequential edit to the profile (such as adding a useless space in the text), and the profile saves as intended.
PS - One possible cause for this behavior is that some format changes, such as adding italics, that are made via the formatting menu don't seem to be recognized as changes. This was true before the new saving system was created.