I tend to use the spelling that is used most often, such as LNAB, marriage, birth of children, death, grave. If there isn’t one that stands out most, then I default to the birth spelling. But I do also mention alternate spellings in case other researchers are looking under a different spelling.
On my husband’s side, he is related to the Tirrells, Terrills, Tirrills, Tyrrells. His branch used Tyrrell for the last several generations and my husband’s middle name is Tyrrell.