Thank you! All the responses are very helpful! My co-worker and most of her family are really excited about this, I'm just worried both sides are going to find "evidence" where there really is none just to prove an outcome they want.
She has sisters who may have been tested already, trick will be to either get everyone over to GEDmatch, or to have the others retest with 23 and Me.
I think he is working on getting his records, seems he was born in Denver but adopted out of Omaha. I'm thinking he probably needs to make inquiries in both States.