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These brothers John W and George W Andrew apparently married sisters Nancy and Ann Eliza Downs. John and George appear to be sons of Cyrus and Clarissa (Shepard) Andrew. James and Phebe (Shaw) Downs are parents of Nancy and Ann. This will require more checking for confirmation. Living in adjacent households in 1870.
U S Census, 1850 Vernon, Clinton, OH
Citing this Record "United States Census, 1850," index and images, FamilySearch (https://familysearch.org/pal:/MM9.1.1/MX3L-VWG
Cyrus Andrew M 24 Ohio
Clarissa Andrew F 22 Ohio
George W Andrew M 3 Ohio
John W Andrew M 1 Ohio
Ohio, County Marriages, 1789-1994
Image/Source: https://familysearch.org/pal:/MM9.3.1/TH-1951-22434-35768-62?cc=1614804&wc=M9MV-3YJ:n399504886
John W. Andrew
Marriage 18 May 1872 Clinton, OH
Spouse Nancy Downs
Image/Source: https://familysearch.org/pal:/MM9.3.1/TH-1942-22434-35479-71?cc=1614804&wc=M9MV-3YJ:n399504886
George W. Andrew
Marriage 03 Jul 1872 Clinton, OH
Spouse Ann Eliza Downs
U S Census, 1870 Vernon, Clinton, OH
Image/Source: https://familysearch.org/pal:/MM9.3.1/TH-267-11603-18981-18?cc=1438024&wc=M9SM-611:184230657
Cyrus Andrew M 44y Ohio
Clarissa Andrew F 43y OH (maiden name Shepard on other records)
George Andrew M 22y OH
John Andrew M 21y OH
Susan Andrew F 18y OH
Elizabeth Andrew F 16y OH
Henry Andrew M 11y OH
Charles Andrew M 9y OH
Nancy Andrew F 7y OH
Eli Andrew M 5y OH
Elmer Andrew M 2y OH
United States Census, 1870 Vernon, Clinton, OH
Image/Source: https://familysearch.org/pal:/MM9.3.1/TH-267-11603-18981-18?cc=1438024&wc=M9SM-611:184230657
James Downs M 43y OH
Anna Downs F 19y OH
Nancy Downs F 17y OH
Sarah Downs F 16y OH
Eleander Downs M 9y OH
Cynthia Downs F 7y OH
Mary Downs F 85y SC
U S Census, 1860 Vernon Township, Clinton OH (Page: 230 more listed only some shown)
https://familysearch.org/search/record/results#count=20&query=%2Bsurname%3Adowns~%20%2Bresidence_place%3A%22Clinton%2C%20Ohio%22~%20%2Bresidence_year%3A1860-1870~
James Downs 35 M
Phebe Downs 30 F (maiden name Shaw on other records)
Delilah Downs 10 F
Nancy Downs 7 F
Ann Downs 9 F