Prior was born about 1801 in Anderson County, SC. He was the son of David Anderson and Mary Barnes. He married Mary Watts "Polly" Duckworth. They had 6 children: Daniel O'Neal "Nealy" Anderson, Hester Elizabeth Anderson, Mary Margaret (Anderson) Grambell, Susan Ann Anderson, James Robert Anderson, Sr. and Benjamin David Anderson. He passed away in May of 1843 in Smith County, MS at age 37-44.
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