From Geni this information is given regarding his Will: [1]
William Drew of the Ninety Six District of South Carolina, Will dated 14 Feb 1777,Proved 15 March 1786 Book.A. Page 1(Part of Page 1 DESTROYED) Names the following children. Sons, Langston and William. Dau's Lucy, Polly, Sarah and Elizabeth. Wife Sarah & Paul of her E.T(do not know what E.T. means.)
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There is an active Y DNA study going on for the Drews. So far there are no samples from the South Carolina group, but that may someday change as more Drew ancestors trace themselves back to Virginia and the Carolinas.
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Link to comparision chart for Y DNA groups: https://www.familytreedna.com/public/drew?iframe=ycolorized
Link to pedigree/patriarch charts from same study: https://www.familytreedna.com/groups/drew/about/results