I do. Actually found recently that I'm descended from more than one, but my "solid" is Edward Fuller. He died not long after they arrived , but did sign the Mayflower Compact.
I have a notification to go back and look at additional passengers, but I stuck a pin in that for a bit. I'm trying to do too much at once, so things are not done as well as I would like, so I haven't even written the other passenger(s?) names down. Amazing there are so many of us. Is 35 million accurate?
I am also directly descended from Robert Hunt, the ship's chaplain who was then the Chaplain in Jamestown (my mind has been very 17th Century today!) and died not long after arriving. That has been an interesting story as well, only found out today (on my b-day!) that he is definitely "our" Robert Hunt. I thought I was part of a Virginia Project, so I need to check that ASAP.